Invitrogen™ GDF6 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA514394

Catalog No. PIPA514394

Description

This antibody is predicted to react with bovine and rat based on sequence homology.

GDF6 is a growth differentiation factor (GDFs), which are members of the transforming growth factor (TGF) superfamily that is involved in embryonic development and adult tissue homeostasis. Both GDF6 and GDF7 are closely related to GDF5 which has been shown to induce activation of plasminogen activator, thereby inducing angiogenesis. It is predominantly expressed in long bones during fetal embryonic development and is involved in bone formation. In Xenopus, GDF6 is expressed at the edge of the neural plate and within the anterior neural plate including the eye fields. GDF6 is required for normal formation of some bones and joints in the limbs, skull, and axial skeleton. It may regulate patterning of the ectoderm by interacting with bone morphogenetic proteins (BMPs), and control eye development. Mutations in this gene result in colobomata, which are congenital abnormalities in ocular development, and in Klippel-Feil syndrome (KFS), a congenital disorder of spinal segmentation.

Specifications

• Antigen: GDF6
• Classification: Polyclonal
• Formulation: PBS with 0.09% sodium azide; pH 7.4
• Gene Accession No.: P43028, Q6KF10
• Gene Symbols: GDF6
• Immunogen: KLH conjugated synthetic peptide between 326-353 amino acids from the C-terminal region of human GDF6.
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
• Conjugate: Unconjugated
• Gene: GDF6
• Gene Alias: BMP13; BMP-13; Bone morphogenetic protein 13; CDMP2; GDF16; GDF6; Gdf-6; growth differentiation factor 16; growth differentiation factor 6; growth/differentiation factor 16; Growth/differentiation factor 6; KFM; KFS; KFS1; KFSL; Klip-Feil malformation; Klippel-Feil malformation; Klippel-Feil syndrome; LCA17; MCOP4; MCOPCB6; SCDO4; SGM1
• Host Species: Rabbit
• Purification Method: Ammonium sulfate precipitation, Size-exclusion - Dialysis
• Regulatory Status: RUO
• Gene ID (Entrez): 242316, 392255
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid