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GDNFRA Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501980138
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50-198-0138 100 μL
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Catalog No. 50-198-0138 Supplier Bioss Supplier No. BS0201R
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Description

Rabbit Polyclonal Antibody

Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for central and peripheral neurons and is essential for the development of kidneys and the enteric nerves system. Physiological responses to GDNF require the presence of a novel glycosylphosphadidylinositol linked protein GDNFRalpha, which is a cell surface receptor for GDNF. The cDNAs encoding GDNFRalpha from human, rat, chicken and mouse have been cloned recently. GDNFRalpha was also termed Ret ligand 1 (RETL1) or TGF-beta-related neurotrophic factor receptor 1 (TrnR1) and nominated as GFR-a-1 recently. GFR-a-1 binds GDNF specifically and mediates activation of the Ret protein tyrosine kinase (PTK). Thus, GDNF, GFR-a and the Ret PTK form a complex to transduce GDNF signal and to mediate GDNF function.

Specifications

Antigen GDNFRA
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene GFRA1
Gene Accession No. P56159
Gene Alias AU042498; DKFZp313E1012; DKFZp686J0156; FLJ10561; FLJ31546; GDNF family receptor alpha 1; GDNF family receptor alpha-1; GDNF receptor alpha; GDNF receptor alpha-1; GDNFR; Gdnfra; GDNFR-alpha; GDNFR-alpha-1; GFR alpha-1; Gfra1; GFR-ALPHA-1; glial cell line derived neurotrophic factor family receptor alpha 1; Glial cell line-derived neurotrophic factor receptor alpha; GPI-linked anchor protein; MGC23045; PI-linked cell-surface accessory protein; RET ligand 1; RET1L; Retl1; TGF-beta-related neurotrophic factor receptor 1; Trnr1
Gene Symbols GFRA1
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human GFR Alpha-1.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2674
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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