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Alfa Aesar™ Geldanamycin, 99+%

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Quantity:
25mg
100mg
250mg
30562-34-6
C29H40N2O9
560.644
MFCD00274570
QTQAWLPCGQOSGP-KDFVLELPSA-N
NSC 122750; U-29135
133688416
[(3S,5R,6S,7R,8Z,11R,14E)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate
CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)OC)C)OC)OC(=O)N)C)C)O)OC
30562-34-6
C29H40N2O9
560.644
MFCD00274570
QTQAWLPCGQOSGP-KDFVLELPSA-N
NSC 122750; U-29135
133688416
[(3S,5R,6S,7R,8Z,11R,14E)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate
CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)OC)C)OC)OC(=O)N)C)C)O)OC

Benzoquinoid antibiotic that inhibits pp60src tyrosine kinase

Applications
Geldanamycin binds to and inhibits the cytosolic chaperone functions of heat shock protein 90 (HSP90). HSP90 maintains the stability and functional shape of many oncogenic signaling proteins. It interferes with conformational maturation of proteins and the cellular stress response. In addition, it is a potent inhibitor of the nuclear hormone receptor family.

Solubility
Soluble in dimethyl sulfoxide at 100 mg/mL.

Notes
Store in a cool dry place. Keep away from oxidizing agents. Protect from heat.
Formula Weight 560.64
Physical Form Powder
Percent Purity ≥99%
Color Yellow to Orange
Quantity 100mg
Chemical Name or Material Geldanamycin

RTECSNumber : LX8920000

Recommended Storage : −30° to −10°C