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Invitrogen™ Gemin 2 Monoclonal Antibody (2E17)
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Catalog No. 01674891
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100 μL
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Catalog No. Quantity
01-674-891 100 μL
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Catalog No. 01-674-891 Supplier Invitrogen™ Supplier No. MA15777
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Description

Mouse Monoclonal Antibody

MA1-5777 detects Gemin2 in human and xenopus samples. MA1-5777 has been successfully used in Western blot, immunoprecipitation, immunofluorescence and ELISA procedures. MA1-5777 detects a band of approximately 34 kDa. The MA1-5777 immunogen is His-Gemin2 (starting at 2nd methionine). Store at 4ºC for one month, or in small aliquots at -20ºC for longer periods.

SIP1 is one of the proteins found in the SMN complex, which consists of the survival of motor neuron (SMN) protein and several gemin proteins. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. SIP1 interacts directly with the SMN and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration. However, knockdown of the SIP1 mRNA in motor neurons showed normal motor axons while that of SMN mRNA did show abnormal motor axon outgrowth, indicating that SIP1 may have additional roles outside of the SMN complex.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Gemin 2
Applications ELISA, Flow Cytometry, Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 2E17
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% sodium azide
Gene GEMIN2
Gene Accession No. O14893, Q9CQQ4
Gene Alias 1700012N19Rik; Component of gems 2; gem (nuclear organelle) associated protein 2; gem nuclear organelle associated protein 2; gem nuclear organelle associated protein 2 S homeolog; gem-associated protein 2; GEMIN2; Gemin-2; gemin2.S; SIP 1; SIP1; SIP-1; SIP1 delta; sip1-delta; SMN interacting protein 1-delta; SMN interacting protein-1; SMN-interacting protein 1; survival of motor neuron protein interacting protein 1; Survival of motor neuron protein-interacting protein 1; survivor of motor neuron protein interacting protein 1; XELAEV_18042638mg
Gene Symbols GEMIN2, gemin2.S
Host Species Mouse
Immunogen His-Gemin 2 fusion protein (amino acids 12 - 280, starting at 2nd methionine).
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 494588, 66603, 8487
Target Species Human, Mouse, Frog
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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