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Invitrogen™ Gemin 2 Polyclonal Antibody
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Catalog No. PIPA591921
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100 μL
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PIPA591921 100 μL
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Catalog No. PIPA591921 Supplier Invitrogen™ Supplier No. PA591921
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Description

Rabbit Polyclonal Antibody

Positive Samples: Jurkat; Cellular Location: Cytoplasm, Nucleus, gem Immunogen sequence: LSIVSRMNQA TVTSVLEYLS NWFGERDFTP ELGRWLYALL ACLEKPLLPE AHSLIRQLAR RCSEVRLLVD SKDDERVPAL NLLICLVSRY FDQRDLADEP S.

SIP1 is one of the proteins found in the SMN complex, which consists of the survival of motor neuron (SMN) protein and several gemin proteins. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. SIP1 interacts directly with the SMN and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration. However, knockdown of the SIP1 mRNA in motor neurons showed normal motor axons while that of SMN mRNA did show abnormal motor axon outgrowth, indicating that SIP1 may have additional roles outside of the SMN complex.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Gemin 2
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.47 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene GEMIN2
Gene Accession No. O14893, Q9CQQ4, Q9QZP1
Gene Alias 1700012N19Rik; Component of gems 2; gem (nuclear organelle) associated protein 2; gem nuclear organelle associated protein 2; gem nuclear organelle associated protein 2 S homeolog; gem-associated protein 2; GEMIN2; Gemin-2; gemin2.S; SIP 1; SIP1; SIP-1; SIP1 delta; sip1-delta; SMN interacting protein 1-delta; SMN interacting protein-1; SMN-interacting protein 1; survival of motor neuron protein interacting protein 1; Survival of motor neuron protein-interacting protein 1; survivor of motor neuron protein interacting protein 1; XELAEV_18042638mg
Gene Symbols GEMIN2
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence within amino acids 180-280 of human Gemin 2 (NP_003607.1).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 66603, 84404, 8487
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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