Invitrogen™ Gemin 2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA591921

Catalog No. PIPA591921

Description

Positive Samples: Jurkat; Cellular Location: Cytoplasm, Nucleus, gem Immunogen sequence: LSIVSRMNQA TVTSVLEYLS NWFGERDFTP ELGRWLYALL ACLEKPLLPE AHSLIRQLAR RCSEVRLLVD SKDDERVPAL NLLICLVSRY FDQRDLADEP S.

SIP1 is one of the proteins found in the SMN complex, which consists of the survival of motor neuron (SMN) protein and several gemin proteins. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. SIP1 interacts directly with the SMN and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration. However, knockdown of the SIP1 mRNA in motor neurons showed normal motor axons while that of SMN mRNA did show abnormal motor axon outgrowth, indicating that SIP1 may have additional roles outside of the SMN complex.

Specifications

• Antigen: Gemin 2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GEMIN2
• Gene Alias: 1700012N19Rik; Component of gems 2; gem (nuclear organelle) associated protein 2; gem nuclear organelle associated protein 2; gem nuclear organelle associated protein 2 S homeolog; gem-associated protein 2; GEMIN2; Gemin-2; gemin2.S; SIP 1; SIP1; SIP-1; SIP1 delta; sip1-delta; SMN interacting protein 1-delta; SMN interacting protein-1; SMN-interacting protein 1; survival of motor neuron protein interacting protein 1; Survival of motor neuron protein-interacting protein 1; survivor of motor neuron protein interacting protein 1; XELAEV_18042638mg
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 66603, 84404, 8487
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.47 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: O14893, Q9CQQ4, Q9QZP1
• Gene Symbols: GEMIN2
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 180-280 of human Gemin 2 (NP_003607.1).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG