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Gemin 2/SMA Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501981478
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50-198-1478 100 μL
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Catalog No. 50-198-1478 Supplier Bioss Supplier No. BS11562R
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Description

Rabbit Polyclonal Antibody

SIP1 is one of the proteins found in the SMN complex, which consists of the survival of motor neuron (SMN) protein and several gemin proteins. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. SIP1 interacts directly with the SMN and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration. However, knockdown of the SIP1 mRNA in motor neurons showed normal motor axons while that of SMN mRNA did show abnormal motor axon outgrowth, indicating that SIP1 may have additional roles outside of the SMN complex.

Specifications

Antigen Gemin 2/SMA
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene GEMIN2
Gene Accession No. O14893
Gene Alias 1700012N19Rik; Component of gems 2; gem (nuclear organelle) associated protein 2; gem nuclear organelle associated protein 2; gem nuclear organelle associated protein 2 S homeolog; Gem-associated protein 2; GEMIN2; Gemin-2; gemin2.S; SIP 1; SIP1; SIP-1; SIP1 delta; sip1-delta; SMN interacting protein 1-delta; SMN interacting protein-1; SMN-interacting protein 1; survival of motor neuron protein interacting protein 1; Survival of motor neuron protein-interacting protein 1; survivor of motor neuron protein interacting protein 1; XELAEV_18042638mg
Gene Symbols GEMIN2
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human Gemin 2.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 8487
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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