Invitrogen™ Gemin 3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5120950

Catalog No. PIPA5120950

Description

Positive test controls include: MCF7, ES-2, 293T, HepG2, HeLa, Mouse spleen, Rat testis, Mouse ovary. The target is usually found in the following locations: Cytoplasm, Nucleus, gem. Immunogen sequence: VQVPAPEPTP GPVRILRTAQ DLSSPRTRTG DVLLAEPADF ESLLLSRPVL EGLRAAGFER PSPVQLKAIP LGRCGLDLIV QAKSGTGKTC VFSTIALDSL VLENLSTQIL ILAPTREIAV QIHSVITAIG IKMEGLECHV FIGGTPLSQD KTRLKKCHIA VGSPGRIKQL IELDYLNPGS IRLFILDEAD KLLEEGSFQE QINWIYSSLP ASKQMLAVSA TYPEFLANAL TKYMRDPTFV RLNSSDPSLI GLKQYY.

Gemin 3 is a member of the DEAD box protein family which are characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD) and are putative RNA helicases. DEAD box proteins such as Gemin 3 are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of DEAD box family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. Gemin 3 has an ATPase activity and a component of the survival of motor neurons (SMN) complex. The Gemin 3 protein may play a catalytic role in the function of the SMN complex on RNPs. Diseases associated with Gemin 3 protein dysfunction include spinal muscular dystrophy and muscular atrophy.

Specifications

• Antigen: Gemin 3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Ddx20
• Gene Alias: component of gems 3; DDX 20; DDX20; DEAD (Asp-Glu-Ala-Asp) box polypeptide 20; DEAD box protein 20; DEAD box protein DP 103; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 20; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 20, 103kD; DEAD/H BOX 20; DEAD-box helicase 20; DEAD-box protein DP103; DKFZP434H052; DP 103; Dp103; GEMIN3; Gemin-3; I79_021005; probable ATP-dependent RNA helicase DDX20; putative ATP-dependent RNA helicase DDX20; regulator of steroidogenic factor 1; ROSF-1; SMN-interacting protein
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11218, 53975, 84473
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot, Immunocytochemistry
• Concentration: 1.04 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q9JJY4, Q9UHI6
• Gene Symbols: Ddx20
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 25-280 of human DDX20 (NP_009135.4).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG