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Invitrogen™ Gemin 5 Polyclonal Antibody
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Catalog No. PIPA5116720
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100 μL
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PIPA5116720 100 μL
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Catalog No. PIPA5116720 Supplier Invitrogen™ Supplier No. PA5116720
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Description

Rabbit Polyclonal Antibody

Positive Samples: HeLa Immunogen sequence: RTPVKLESID GNEEESMKEN SGPVENGVSD QEGEEQAREP ELPCGLAPAV SREPVICTPV SSGFEKSKVT INNKVILLKK EPPKEKPETL IKKRKARSLL PLSTSLDHRS KEELHQDCLV LATAKHSREL NEDVSADVEE RFHLGLFTDR ATLYRMIDIE GKGHLENGHP ELFHQLMLWK GDLKGVLQTA AERGELTDNL V.

The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. GEMIN5 acts as the snRNA-binding protein of the SMN complex.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Gemin 5
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1.92 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene GEMIN5
Gene Accession No. Q8BX17, Q8TEQ6
Gene Alias AA407055; AA407208; AI451603; BB194447; C330013N08; gem (nuclear organelle) associated protein 5; gem nuclear organelle associated protein 5; gem-associated protein 5; Gemin5; GEMIN-5
Gene Symbols GEMIN5
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 750-950 of human GEMIN5 (NP_0562802).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 216766, 25929, 691231
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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