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GEMIN2 Monoclonal Antibody (OTI4A2), TrueMAB™, OriGene
SDP

Catalog No. 501682398
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50-168-2398 100 μL
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Catalog No. 50-168-2398 Supplier OriGene Supplier No. TA808824
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Description

Mouse Monoclonal Antibody

SIP1 is one of the proteins found in the SMN complex, which consists of the survival of motor neuron (SMN) protein and several gemin proteins. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. SIP1 interacts directly with the SMN and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration. However, knockdown of the SIP1 mRNA in motor neurons showed normal motor axons while that of SMN mRNA did show abnormal motor axon outgrowth, indicating that SIP1 may have additional roles outside of the SMN complex.

Specifications

Antigen GEMIN2
Applications Western Blot
Classification Monoclonal
Clone OTI4A2
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene GEMIN2
Gene Accession No. O14893
Gene Alias SIP1, SIP1-delta
Gene Symbols GEMIN2
Host Species Mouse
Immunogen Full length human recombit protein of human SIP1 produced in E.coli.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 8487
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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