Invitrogen™ GEMIN8 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA598913

Catalog No. PIPA598913

Description

GEMIN8 Polyclonal Antibody for Western Blot, IHC (P), ELISA

The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus.

Specifications

• Antigen: GEMIN8
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GEMIN8
• Gene Alias: B130034M20Rik; B930082C09Rik; BC023488; Fam51a1; family with sequence similarity 51, member A1; family with sequence similarity 51, member A1 homolog; gem (nuclear organelle) associated protein 8; gem nuclear organelle associated protein 8; gem-associated protein 8; GEMIN8; Gemin-8; Protein FAM51A1
• Host Species: Rabbit
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 237221, 54960
• Content And Storage: -20°C or -80°C if preferred
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 2 mg/mL
• Formulation: PBS with 50% glycerol and 0.03% ProClin 300; pH 7.4
• Gene Accession No.: Q8BHE1, Q9NWZ8
• Gene Symbols: GEMIN8
• Immunogen: Recombinant Human Gem-associated protein 8 protein (1-242AA).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG