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Invitrogen™ GEMIN8 Polyclonal Antibody
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Catalog No. PIPA5103503
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PIPA5103503 100 μL
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Catalog No. PIPA5103503 Supplier Invitrogen™ Supplier No. PA5103503
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total GEMIN8.

The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GEMIN8
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene GEMIN8
Gene Accession No. Q8BHE1, Q9NWZ8
Gene Alias B130034M20Rik; B930082C09Rik; BC023488; Fam51a1; family with sequence similarity 51, member A1; family with sequence similarity 51, member A1 homolog; gem (nuclear organelle) associated protein 8; gem nuclear organelle associated protein 8; gem-associated protein 8; GEMIN8; Gemin-8; Protein FAM51A1
Gene Symbols GEMIN8
Host Species Rabbit
Immunogen A synthesized peptide derived from human GEMIN8(Accession Q9NWZ8), corresponding to amino acid residues R203-F242.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 237221, 363462, 54960
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

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