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Invitrogen™ GEN1 Polyclonal Antibody
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Catalog No. PIPA554137
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100 μL
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PIPA554137 100 μL
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Catalog No. PIPA554137 Supplier Invitrogen™ Supplier No. PA554137
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: SILSVKESCI ANSGSDCTSH LSKDLPGIPL QNESRDSKIL KGDQLLQEDY KVNTSVPYSV SNTVVKTCNV RPPNTALDHS RKVDMQTTRK ILMKKSVCLD RHSSDEQSAP VFGKAKYTTQ RMKHSSQKHN SSHFKESGHN KLSSPKI Highest antigen sequence identity to the following orthologs: Mouse - 50%, Rat - 47%.

Xeroderma pigmentosum type G (XPG) is a human genetic disease exhibiting extreme sensitivity to sunlight. The XPG protein, a member of the flap endonuclease 1 (FEN-1) structure-specific DNA repair endonuclease family, is an enzyme essential for DNA repair of the major kinds of solar ultraviolet (UV)-induced DNA damages. Human XPG nuclease makes the 3' incision during nucleotide excision repair of DNA. The enzyme cleaves model DNA bubble structures specifically near the junction of unpaired DNA with a duplex region. A 29-amino acid region of human XPG (residues 981-1009) contains the PCNA binding activity. A conserved arginine in XPG (Arg992) is crucial for its PCNA binding activity. Replication Protein A (RPA) binds specifically and directly to two excision repair proteins, the xeroderma pigmentosum damage-recognition protein XPA and the endonuclease XPG.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GEN1
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene GEN1
Gene Accession No. Q17RS7
Gene Alias 5830483C08Rik; Flap endonuclease GEN homolog 1; Gen; Gen endonuclease homolog 1; Gen homolog 1, endonuclease; Gen homolog 1, endonuclease (Drosophila); GEN1; GEN1 Holliday junction 5' flap endonuclease; GEN1, Holliday junction 5' flap endonuclease; Holliday junction resolvase; RGD1559792
Gene Symbols GEN1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human GEN1. Recombinant protein control fragment (Product #RP-92437).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 348654
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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