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Thermo Scientific™ GeneBLAzer™ RXRβ-UAS-bla HEK 293T Cells

Catalog No. K1694
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2 x 106 cells
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K1694 2 x 106 cells
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Catalog No. K1694 Supplier Thermo Scientific™ Supplier No. K1694
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Description

RXR beta-UAS-bla HEK 293T cells contain the ligand-binding domain (LBD) of the human Retinoid X Receptor beta (RXR beta) fused to the DNA-binding domain of GAL4 stably integrated in the GeneBLAzer™UAS-bla HEK 293T cell line.

RXR beta-UAS-bla HEK 293T cells contain the ligand-binding domain (LBD) of the human Retinoid X Receptor beta (RXR beta) fused to the DNA-binding domain of GAL4 stably integrated in the GeneBLAzer™UAS-bla HEK 293T cell line. GeneBLAzer™UAS-bla HEK 293T cells stably express a beta-lactamase reporter gene under the transcriptional control of an upstream activator sequence (UAS). When an agonist binds to the LBD of the GAL4 (DBD)-RXR beta (LBD) fusion protein, the protein binds to the UAS, resulting in expression of beta-lactamase. RXR beta-UAS-bla HEK 293T cells are functionally validated for Z' and EC50 concentrations of 9-cis retinoic acid (9-cis-RA). In addition, RXR beta-UAS-bla HEK 293T cells have been tested for assay performance under variable conditions, including DMSO concentration, cell number, and stimulation time.

TRUSTED_SUSTAINABILITY

Specifications

Alternate Agonists Progesterone
Antagonists RU 486
Assay Entry Cell-based beta lactamase reporter gene
Cell State Dividing Cells
Content And Storage RXR beta-UAS-bla HEK 293T cells (K1259)

Shipping: Dry Ice
Storage: -80°C (liquid nitrogen)
Detection Method Fluorescence
Druggable Target Nuclear Receptors
No. of Cells 2 x 106 Cells
Primary Agonist R5020
Product Line GeneBLAzer
Product Type HEK 293T Cells
Quantity 2 x 106 cells
Reporter Gene BLA (Beta-Lactamase)
Target Entry RXR beta, NR2B2, RXRB
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For Research Use Only. Not for use in diagnostic procedures.

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