GFI1 Monoclonal Antibody (OTI6H7), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA805546

Catalog No. 50-168-0747

Description

Gfi-1 is a nuclear zinc finger (ZF) transcriptional repressor that plays an important role in hematopoiesis and inner ear development, and has been implicated in lymphomagenesis. The Gfi1 protein expression is regulated by the ubiquitin-proteasome system. It is reported that ubiquitin ligase Triad1 interacts with the DNA-binding domain of Gfi-1. Gfi-1 represses transcription by directly binding to the consensus DNA sequence in the promoters of its target genes. Deficiency of Gfi-1 causes neutropenia and an accumulation of granulomonocytic precursor cells that is reminiscent of a myelodysplastic syndrome in mice.

Specifications

• Antigen: GFI1
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q99684
• Gene Symbols: GFI1
• Immunogen: Human recombit protein fragment corresponding to amino acids 1-180 of human GFI1 produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Western Blot
• Clone: OTI6H7
• Conjugate: Unconjugated
• Gene: GFI1
• Gene Alias: GFI-1, GFI1A, SCN2, ZNF163
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 2672
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid