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Invitrogen™ GFI1 Polyclonal Antibody
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Catalog No. PIPA5116697
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100 μL
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PIPA5116697 100 μL
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Catalog No. PIPA5116697 Supplier Invitrogen™ Supplier No. PA5116697
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Description

Rabbit Polyclonal Antibody

Positive Samples: Mouse spleen, Rat thymus, Rat spleen Immunogen sequence: MPRSFLVKSK KAHSYHQPRS PGPDYSLRLE NVPAPSRADS TSNAGGAKAE PRDRLSPESQ LTEAPDRASA SPDSCEGSVC ERSSEFEDFW RPPSPSASPA.

GFI1 is a nuclear zinc finger (ZF) transcriptional repressor that plays an important role in hematopoiesis and inner ear development, and has been implicated in lymphomagenesis. The Gfi1 protein expression is regulated by the ubiquitin-proteasome system. It is reported that ubiquitin ligase Triad1 interacts with the DNA-binding domain of Gfi-1. Gfi-1 represses transcription by directly binding to the consensus DNA sequence in the promoters of its target genes. Deficiency of Gfi-1 causes neutropenia and an accumulation of granulomonocytic precursor cells that is reminiscent of a myelodysplastic syndrome in mice.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GFI1
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 3.02 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene GFI1
Gene Accession No. P70338, Q07120
Gene Alias AW495828; FLJ94509; Gfi1; GFI-1; GFI1A; growth factor independence-1; growth factor independent 1; growth factor independent 1 transcription repressor; growth factor independent 1 transcriptional repressor; growth factor independent protein 1; Growth factor independent-1; Pal1; Pal-1; SCN2; Zinc finger protein 163; zinc finger protein Gfi-1; ZNF163
Gene Symbols GFI1
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence within amino acids 1-100 of human GFI1 (NP_0011206871).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 14581, 24388
Target Species Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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