GFI1 Polyclonal Antibody, Active Motif™

Rabbit Polyclonal Antibody

Supplier:  Active Motif 61554

Catalog No. 50-199-3491

Description

GFI1 is a nuclear zinc finger (ZF) transcriptional repressor that plays an important role in hematopoiesis and inner ear development, and has been implicated in lymphomagenesis. The Gfi1 protein expression is regulated by the ubiquitin-proteasome system. It is reported that ubiquitin ligase Triad1 interacts with the DNA-binding domain of Gfi-1. Gfi-1 represses transcription by directly binding to the consensus DNA sequence in the promoters of its target genes. Deficiency of Gfi-1 causes neutropenia and an accumulation of granulomonocytic precursor cells that is reminiscent of a myelodysplastic syndrome in mice.

Specifications

• Antigen: GFI1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GFI1
• Gene Alias: AW495828; FLJ94509; GFI1; Gfi-1; GFI1A; growth factor independence-1; growth factor independent 1; growth factor independent 1 transcription repressor; growth factor independent 1 transcriptional repressor; Growth factor independent protein 1; Growth factor independent-1; Pal1; Pal-1; SCN2; Zinc finger protein 163; Zinc finger protein Gfi-1; ZNF163
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 2672
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: Lot-Specific
• Formulation: PBS with 30% glycerol and 0.035% sodium azide; pH 7.5
• Gene Accession No.: Q99684
• Gene Symbols: GFI1
• Immunogen: This antibody was raised against a peptide within the N-terminal region of human GFI1.
• Quantity: 10 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG