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GFI1 Polyclonal Antibody, Active Motif™
SDP

Catalog No. 501993491
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100 μL
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50-199-3491 10 μL
50-199-3490 100 μL
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Catalog No. 50-199-3491 Supplier Active Motif Supplier No. 61554
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Description

Rabbit Polyclonal Antibody

GFI1 is a nuclear zinc finger (ZF) transcriptional repressor that plays an important role in hematopoiesis and inner ear development, and has been implicated in lymphomagenesis. The Gfi1 protein expression is regulated by the ubiquitin-proteasome system. It is reported that ubiquitin ligase Triad1 interacts with the DNA-binding domain of Gfi-1. Gfi-1 represses transcription by directly binding to the consensus DNA sequence in the promoters of its target genes. Deficiency of Gfi-1 causes neutropenia and an accumulation of granulomonocytic precursor cells that is reminiscent of a myelodysplastic syndrome in mice.

Specifications

Antigen GFI1
Applications Western Blot
Classification Polyclonal
Concentration Lot-Specific
Conjugate Unconjugated
Formulation PBS with 30% glycerol and 0.035% sodium azide; pH 7.5
Gene GFI1
Gene Accession No. Q99684
Gene Alias AW495828; FLJ94509; GFI1; Gfi-1; GFI1A; growth factor independence-1; growth factor independent 1; growth factor independent 1 transcription repressor; growth factor independent 1 transcriptional repressor; Growth factor independent protein 1; Growth factor independent-1; Pal1; Pal-1; SCN2; Zinc finger protein 163; Zinc finger protein Gfi-1; ZNF163
Gene Symbols GFI1
Host Species Rabbit
Immunogen This antibody was raised against a peptide within the N-terminal region of human GFI1.
Purification Method Antigen affinity chromatography
Quantity 10 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2672
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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