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Invitrogen™ GFI1B Polyclonal Antibody
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Catalog No. PIPA535249
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400 μL
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PIPA535249 400 μL
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Catalog No. PIPA535249 Supplier Invitrogen™ Supplier No. PA535249
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Description

Rabbit Polyclonal Antibody

GFI1B Polyclonal Antibody for Western Blot

GFI1b (zinc finger protein GFI-1b) is an essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. It is also a component of a RCOR-GFI-KDM1A-HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. GFI1b also acts as a transcriptional repressor or activator depending on both promoter and cell type context; represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine signaling pathways. It also cooperates with GATA1 to repress target gene transcription, such as the apoptosis regulator BCL2L1; GFI1B silencing in leukemic cell lines markedly increase apoptosis rate. Mutations affecting the gene are associated with Bleeding disorder, platelet-type 17 (BDPLT17).
TRUSTED_SUSTAINABILITY

Specifications

Antigen GFI1B
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.4
Gene GFI1B
Gene Accession No. O70237, Q5VTD9
Gene Alias BDPLT17; GFI1B; Gfi-1B; growth factor independent 1B; growth factor independent 1B (potential regulator of CDKN1A, translocated in CML); growth factor independent 1B transcription repressor; growth factor independent 1B transcriptional repressor; growth factor independent 1B-like protein; growth factor independent protein 1B; growth factor-independent 1B; Potential regulator of CDKN1A translocated in CML; Zinc finger protein Gfi-1b; ZNF163B
Gene Symbols GFI1B
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide between 302-330 amino acids from the C-terminal region of human GFI1B.
Purification Method Antigen affinity chromatography, Protein A
Quantity 400 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 14582, 8328
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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