Invitrogen™ GFRAL Polyclonal Antibody

Sheep Polyclonal Antibody

Supplier:  Invitrogen™ PA547769

Catalog No. PIPA547769

Description

In direct ELISA, less than 1% cross-reactivity with recombinant mouse (rm) GFR alpha -3 and rmGFR alpha -4 is observed. Reconstitute at 0.2 mg/mL in sterile PBS.

Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099). Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways. [UniProt].

Specifications

• Antigen: GFRAL
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GFRAL
• Gene Alias: AY457637; bA360D14.1; C6orf144; GDNF family receptor alpha like; GDNF family receptor alpha-like; GDNF receptor alpha-like; GFRAL; Gral; IVFI9356; RGD1565220; UNQ9356; UNQ9356/PRO34128
• Host Species: Sheep
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 404194
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.2 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: Q6SJE0
• Gene Symbols: GFRAL
• Immunogen: CHO-derived recombinant mouse GFR alpha-like isoform A Gln20-Gly349.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG