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GI24 Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501989434
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50-198-9434 100 μL
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Catalog No. 50-198-9434 Supplier Bioss Supplier No. BS9898R
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Description

Rabbit Polyclonal Antibody

VISTA (V-domain Ig containing suppressor of T-cell activation), also known as B7-H5 or PD-1H, is a product of the VSIR gene. Although VISTA bears sequence homology to PD-L1 it has a different expression pattern. In both mouse and humans, VISTA is expressed predominantly on hematopoietic cells with the highest densities on myeloid cells, and lower levels on T cells. It is usually absent on B cells. VISTA expressed by antigen presenting cells has been shown to directly suppress proliferation and cytokine production of CD4 and CD8 T cells, making it a target for cancer immunotherapy. The reported ligands of VISTA include CD28H, VSIG-3 and VSIG-8.

Specifications

Antigen GI24
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene VSIR
Gene Accession No. Q9H7M9
Gene Alias 4632428N05Rik; B7H5; B7-H5; BOS_24233; C10orf54; C28H10orf54; C4H10orf54; chromosome 10 open reading frame 54; chromosome 28 open reading frame, human C10orf54; chromosome 4 open reading frame, human C10orf54; DD1alpha; Death Domain1alpha; Dies1; differentiation of ESCs 1; GI24; PD-1H; PDCD1 homolog; PD-H1; Platelet receptor Gi24; PP2135; RIKEN cDNA 4632428N05 gene; SISP1; Sisp-1; Stress-induced secreted protein-1; UNQ730/PRO1412; V-domain Ig suppressor of T cell activation; VISTA; V-set domain-containing immunoregulatory receptor; V-set immunoregulatory receptor; VSIR; V-type immunoglobulin domain-containing suppressor of T-cell activation
Gene Symbols VSIR
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human SISP1/GI24.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 64115
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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