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Invitrogen™ GILZ Monoclonal Antibody (CFMKG15), PE, eBioscience™

Rat Monoclonal Antibody

Supplier:  Invitrogen™ 12403382

Encompass_Preferred

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Catalog No. 50-107-70


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Description

Description

Description: GILZ is a leucine-zipper-containing protein that is induced by glucocorticoids. It is expressed in mast cells, monocytes, macrophages, dendritic cells, and T cells. GILZ has been shown to inhibit production of IL-2 as well as TCR-driven upregulation of FasL. GILZ mediates these changes in transcription, at least in part, by inhibiting DNA-binding of the transcription factors AP-1 and NF-kappaB. GILZ has also been shown to mediate anti-inflammatory signals in macrophages and dendritic cells by interfering with NF-kappaB-mediated signaling. Although GILZ has been reported to localize to the nucleus, more recent reports as well as testing at eBioscience have observed predominantly cytoplasmic staining. Applications Reported: This CFMKG15 antibody has been reported for use in intracellular staining followed by flow cytometric analysis and immunocytochemistry. Applications Tested: This CFMKG15 antibody has been tested by intracellular flow cytometric analysis of dexamethasone-treated mouse lymph node cells and human peripheral blood cells. This can be used at less than or equal to 0.5 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. For intracellular staining with CFMKG15, it is recommended t...

The TSC22 domain family member 3 protein (TSC22D3) is a leucine zipper protein that functions as a transcriptional regulator. The expression of TSC22D3 is stimulated by glucocorticoids and IL-10 and is thought to play a key role in the anti-inflammatory and immunosuppressive effects of these molecules. TSC22D3 can physically interact with and inhibit the activities of key inflammatory signaling mediators such NF-Kappa-B and AP-1. TSC22D3 functions as a transcriptional co-activator for various nuclear receptors and NF-Kappa-B. It has also been shown to be involved in the differentiation of mesenchymal stem cells towards osteoblasts and bone formation.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

GILZ
Monoclonal
0.2 mg/mL
PBS with 0.09% sodium azide; pH 7.2
Q99576, Q9Z2S7
TSC22D3
Affinity chromatography
RUO
14605, 1831
4°C, store in dark, DO NOT FREEZE!
Liquid
Flow Cytometry, Immunocytochemistry
CFMKG15
PE
TSC22D3
delta sleep inducing peptide, immunoreactor; delta sleep-inducing peptide immunoreactor; DIP; Dsip1; DSIPI; DSIP-immunoreactive leucine zipper protein; DSIP-immunoreactive peptide; GILZ; glucocorticoid-induced leucine zipper protein; long glucocorticoid-induced leucine zipper protein; Protein DIP; Tilz3; TSC22 domain family 3; TSC22 domain family member 3; TSC22 domain family protein 3; TSC22 domain family, member 3; TSC-22 related protein; TSC22D3; TSC-22-like protein; TSC-22R; TSC22-related inducible leucine zipper 3; TSC-22-related protein; TSC22-related-inducible leucine zipper 3
Rat
100 μg
Primary
Human, Mouse
Antibody
IgG2a κ
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