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Invitrogen™ GIMAP8 Polyclonal Antibody
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Catalog No. PIPA553175
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100 μL
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PIPA553175 100 μL
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Catalog No. PIPA553175 Supplier Invitrogen™ Supplier No. PA553175
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: PDISSLKNID SEVRKHICTG PHAFLLVTPL GFYTKNDEAV LSTIQNNFGE KFFEYMIILL TRKEDLGDQD LDTFLRNSNK ALYGLIQKCK NRYSAFNYRA TGEEEQRQAD ELLEKIESMV HQNGNK Highest antigen sequence identity to the following orthologs: Mouse - 54%, Rat - 56%.

The GIMAP8 gene, part of the GTPase of the Immunity-Associated Proteins (GIMAP) family, is located on chromosome 7q36.1. This gene encodes a protein that is predominantly expressed in immune cells, including T and B lymphocytes. GIMAP8 is involved in the regulation of lymphocyte survival and development, particularly during the early and late stages of T cell development in the thymus, as well as during B cell maturation. Studies have shown that GIMAP8 expression levels are significantly altered in various cancers, including breast and lung adenocarcinoma, where its upregulation in tumor tissues correlates with improved overall survival in specific cancer subtypes. This suggests a potential role for GIMAP8 in tumor immune surveillance and as a prognostic biomarker. Additionally, GIMAP8's functions appear essential but redundant enough that mouse models deficient in this gene do not exhibit major defects in T or B cell development, indicating compensation by other family members.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GIMAP8
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.3 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene GIMAP8
Gene Accession No. Q8ND71
Gene Alias GIMAP8; Gm457; GTPase IMAP family member 8; GTPase, IMAP family member 8; hIAN6; human immune associated nucleotide 6; IAN6; IAN9; IAN-9; Iant; IMAP8; Immune-associated nucleotide-binding protein 9; immunity-associated protein 8; mGIMAP8; Protein IanT
Gene Symbols GIMAP8
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human GIMAP8. Recombinant protein control fragment (Product #RP-90833).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 155038
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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