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Invitrogen™ GIMAP8 Polyclonal Antibody
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Catalog No. PIPA590299
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100 μL
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PIPA590299 100 μL
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Catalog No. PIPA590299 Supplier Invitrogen™ Supplier No. PA590299
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: MSEQSCQMSE LRLLLLGKCR SGKSATGNAI LGKHVFKSKF SDQTVIKMCQ RESWVLRERK VVVIDTPDLF SSIACAEDKQ RNIQHCLELS APSLHALLLV IAIGHFTRED EETAKGIQQV FGAEARRHII IVFTRKDDLG DDLLQDFIEK NKPLKQLVQD YEGRYCIFNN KTNSKDEQIT QVLELLRKVE SLVNTNGGPY HVNFKTEGSR FQDCVNEAAS QEGDKPQGPR ERQLQSTGPE QNPGTSELTV LLVGKRGAGK SAAGNSILGR QAFQTGFSEQ SVTQSFLSES RSWRKKKVSI; Positive Samples: A549, mouse thymus, mouse spleen, rat spleen; Cellular Location: Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Mitochondrion, cytosol.

The GIMAP8 gene, part of the GTPase of the Immunity-Associated Proteins (GIMAP) family, is located on chromosome 7q36.1. This gene encodes a protein that is predominantly expressed in immune cells, including T and B lymphocytes. GIMAP8 is involved in the regulation of lymphocyte survival and development, particularly during the early and late stages of T cell development in the thymus, as well as during B cell maturation. Studies have shown that GIMAP8 expression levels are significantly altered in various cancers, including breast and lung adenocarcinoma, where its upregulation in tumor tissues correlates with improved overall survival in specific cancer subtypes. This suggests a potential role for GIMAP8 in tumor immune surveillance and as a prognostic biomarker. Additionally, GIMAP8's functions appear essential but redundant enough that mouse models deficient in this gene do not exhibit major defects in T or B cell development, indicating compensation by other family members.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GIMAP8
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 1.13 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene GIMAP8
Gene Accession No. Q4KLG2, Q75N62, Q8ND71
Gene Alias GIMAP8; Gm457; GTPase IMAP family member 8; GTPase, IMAP family member 8; hIAN6; human immune associated nucleotide 6; IAN6; IAN9; IAN-9; Iant; IMAP8; Immune-associated nucleotide-binding protein 9; immunity-associated protein 8; mGIMAP8; Protein IanT
Gene Symbols GIMAP8
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human GIMAP8 (NP_7831611).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 155038, 243374, 500112
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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