Invitrogen™ GIMAP8 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA521969

Catalog No. PIPA521969

Description

Recommended positive controls: 293T, A431, H1299, HeLaS3, HepG2. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The GIMAP8 gene, part of the GTPase of the Immunity-Associated Proteins (GIMAP) family, is located on chromosome 7q36.1. This gene encodes a protein that is predominantly expressed in immune cells, including T and B lymphocytes. GIMAP8 is involved in the regulation of lymphocyte survival and development, particularly during the early and late stages of T cell development in the thymus, as well as during B cell maturation. Studies have shown that GIMAP8 expression levels are significantly altered in various cancers, including breast and lung adenocarcinoma, where its upregulation in tumor tissues correlates with improved overall survival in specific cancer subtypes. This suggests a potential role for GIMAP8 in tumor immune surveillance and as a prognostic biomarker. Additionally, GIMAP8's functions appear essential but redundant enough that mouse models deficient in this gene do not exhibit major defects in T or B cell development, indicating compensation by other family members.

Specifications

• Antigen: GIMAP8
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GIMAP8
• Gene Alias: GIMAP8; Gm457; GTPase IMAP family member 8; GTPase, IMAP family member 8; hIAN6; human immune associated nucleotide 6; IAN6; IAN9; IAN-9; Iant; IMAP8; Immune-associated nucleotide-binding protein 9; immunity-associated protein 8; mGIMAP8; Protein IanT
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 155038
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q8ND71
• Gene Symbols: GIMAP8
• Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human GIMAP8. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov