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GITR Ligand Rat anti-Mouse, Brilliant Violet 650, Clone: MIH44, BD Optibuild™

Catalog No. BDB742578 Shop All BD Biosciences Products
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BDB742578 50 μg
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Catalog No. BDB742578 Supplier BD Biosciences Supplier No. 742578
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Description

Rat Monoclonal Antibody

The MIH44 monoclonal antibody specifically binds to Glucocorticoid-induced TNF-related Ligand (GITR Ligand). The GITR Ligand protein is encoded by the Tnfsf18 /( Tumor necrosis factor ligand superfamily member 18 /) gene. The GITR Ligand is a type II transmembrane protein that is expressed on endothelial cells and antigen presenting cells, including B cells, macrophage and dendritic cells. The GITR Ligand reportedly costimulates T cell activation and reverses CD4+CD25+ Treg cell-mediated suppression by interaction with its cognate receptor, GITR that is expressed by these cells.

The antibody was conjugated to BD Horizon™ BV650 which is part of the BD Horizon Brilliant™ Violet family of dyes. This dye is a tandem fluorochrome of BD Horizon BV421 with an Ex Max of 405nm and an acceptor dye with an Em Max at 650nm. BD Horizon BV650 can be excited by the violet laser and detected in a filter used to detect APC-like dyes (eg, 660/20nm filter). Due to the excitation and emission characteristics of the acceptor dye, there will be spillover into the APC and Alexa Fluor™ 700 detectors. However, the spillover can be corrected through compensation as with any other dye combination. BV650 is a tandem fluorochrome of BD Horizon BV421 and an acceptor dye with an emission maximum at 650 nm. Due to the excitation and emission characteristics of the acceptor dye, there will be spillover into the APC and Alexa Fluor™ 700 detectors. BV650 will have moderate spillover into the BD Horizon™ BV711 detector.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GITR Ligand
Classification Monoclonal
Clone MIH44
Concentration 0.2mg/mL
Conjugate Brilliant Violet 650
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Gene Alias Tnfsf18, Gitrl,Glucocorticoid-induced-tumor necrosis factor receptor ligand
Host Species Rat
Immunogen GITRL/GFP-transfected L cells
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG2b κ
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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