Invitrogen™ GITR (TNFRSF18) Recombinant Rabbit Monoclonal Antibody (BLR068G)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA544327

Catalog No. PIMA544327

Description

Epitope retrieval with citrate buffer pH6.0 is recommended for FFPE cell sections.

Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), also called GITR or AITR is a protein that in humans is encoded by the TNFRSF18 gene. It is mapped to 1p36.33. This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25 (+)CD4 (+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Specifications

• Antigen: GITR (TNFRSF18)
• Classification: Recombinant Monoclonal
• Concentration: 1 mg/mL
• Formulation: BBS with 0.09% sodium azide; pH 8.2
• Gene Accession No.: Q9Y5U5
• Gene Symbols: Tnfrsf18
• Immunogen: Peptide representing a region between residue 191 and the C-terminus (residue 241) of human Tumor necrosis factor receptor superfamily member 18 (GITR).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
• Clone: BLR068G
• Conjugate: Unconjugated
• Gene: Tnfrsf18
• Gene Alias: Activation-inducible TNFR family receptor; AITR; CD357; GITR; GITR-D; glucocorticoid-induced TNFR-related protein; PRO364; TNF receptor superfamily activation-inducible protein; TNF receptor superfamily member 18; TNFRSF18; Tumor necrosis factor receptor superfamily member 18; tumor necrosis factor receptor superfamily, member 18; UNQ319; UNQ319/PRO364
• Host Species: Rabbit
• Purification Method: Purified
• Regulatory Status: RUO
• Gene ID (Entrez): 8784
• Content And Storage: 4°C
• Form: Liquid

Safety and Handling

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