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Invitrogen™ GKN1 Monoclonal Antibody (759821)
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Catalog No. PIMA524367
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100 μg
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Catalog No. Quantity
PIMA524367 100 μg
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Catalog No. PIMA524367 Supplier Invitrogen™ Supplier No. MA524367
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Description

Rat Monoclonal Antibody

This antibody detects mouse Gastrokine 1 in direct ELISAs and mouse and rat Gastrokine 1 in Western blots. In Western blots, approximately 10% cross-reactivity with recombinant human (rh) Gastrokine 1 and no cross-reactivity with rhBlottin is observed. Reconstitute in sterile PBS to a final concentration of 0.5 mg/mL.

Gastrokine 1, also known as GKN1 and CA11, is a 185 amino acid containing secreted protein belonging to the gastrokine family with a BRICHOS domain and an asn-rich region. GKN1 (also known as an antioncogene) is reported to be down-regulated in human gastric cancer tissue as compared to normal gastric mucosa. Differential display of normal and cancerous gastric tissue suggested that this protein is predominantly expressed in stomach and the expression is down-regulated to considerable frequency in cancer tissue or gastric cancer cell lines examined. This extra cellular protein is co-secreted with mucins and is a signaling growth factor with mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GKN1
Applications Immunohistochemistry (Frozen), Western Blot
Classification Monoclonal
Clone 759821
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene GKN1
Gene Accession No. Q9CR36
Gene Alias 18 kDa antrum mucosa protein; 2200002K21Rik; Amp18; AMP-18; Amp18; gastrokine; BRICD1; BRICHOS domain containing 1; Ca11; FOV; foveolin; gastrokine 1; gastrokine-1; Gkn1; Protein CA11; Protein CA11 homolog; UNQ489/PRO1005
Gene Symbols GKN1
Host Species Rat
Immunogen E. coli-derived recombinant mouse Gastrokine 1 Tyr38-Tyr201.
Purification Method Protein A/G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 66283
Target Species Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG2a
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