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Invitrogen™ GLE1 Polyclonal Antibody
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Catalog No. PIPA520661
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100 μg
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Catalog No. Quantity
PIPA520661 100 μg
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Catalog No. PIPA520661 Supplier Invitrogen™ Supplier No. PA520661
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Description

Rabbit Polyclonal Antibody

A suggested positive control is 293 cell lysate. PA5-20661 can be used with blocking peptide PEP-0781.

The proper expression of gene products in eukaryotic cells relies on efficient transport of mRNA molecules out of the nucleus. Gle1 is an essential mRNA export factor in both human and yeast cells. It associates with the nuclear pore complex (NPC) through hCG1 and NUP155 in mammalian cells and in conjunction with inositol hexakisphosphate (IP6), stimulates Dbp5, a member of the DEAD-box helicase family, triggering mRNP remodeling and facilitating RNA export from the nucleus. Recent evidence suggests that mutations in Gle1 causing defects in mRNA export can result in human disease. At least three isoforms of Gle1 are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GLE1
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene GLE1
Gene Accession No. Q4KLN4, Q53GS7, Q8R322
Gene Alias 4933405K21Rik; AA553313; GLE1; GLE1 RNA export mediator; GLE1 RNA export mediator (yeast); GLE1 RNA export mediator homolog; GLE1 RNA export mediator-like (yeast; GLE1, RNA export mediator; GLE1L; GLE1-like protein; GLE1-like, RNA export mediator; hGLE1; LCCS; LCCS1; Nucleoporin GLE1
Gene Symbols GLE1
Host Species Rabbit
Immunogen A 14 amino acid peptide near the center of human Gle1.
Purification Method Antigen Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2733, 362098, 74412
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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