Invitrogen™ GLE1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA583571

Catalog No. PIPA583571

Description

Immunogen sequence: DESQHTESMV LQSSRGIKVE GCVRMYELVH RMKGTEGLRL WQEEQERKVQ ALSEMASEQL KRFDEWKELK QHKEFQDLRE VMEKSSREAL GHQEKLKAEH R.

The proper expression of gene products in eukaryotic cells relies on efficient transport of mRNA molecules out of the nucleus. Gle1 is an essential mRNA export factor in both human and yeast cells. It associates with the nuclear pore complex (NPC) through hCG1 and NUP155 in mammalian cells and in conjunction with inositol hexakisphosphate (IP6), stimulates Dbp5, a member of the DEAD-box helicase family, triggering mRNP remodeling and facilitating RNA export from the nucleus. Recent evidence suggests that mutations in Gle1 causing defects in mRNA export can result in human disease. At least three isoforms of Gle1 are known to exist.

Specifications

• Antigen: GLE1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GLE1
• Gene Alias: 4933405K21Rik; AA553313; GLE1; GLE1 RNA export mediator; GLE1 RNA export mediator (yeast); GLE1 RNA export mediator homolog; GLE1 RNA export mediator-like (yeast; GLE1, RNA export mediator; GLE1L; GLE1-like protein; GLE1-like, RNA export mediator; hGLE1; LCCS; LCCS1; Nucleoporin GLE1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 2733
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.4 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q53GS7
• Gene Symbols: GLE1
• Immunogen: Recombinant protein corresponding to Human GLE1. Recombinant protein control fragment (Product #RP-98406).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG