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Invitrogen™ GLE1 Polyclonal Antibody
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Catalog No. PIPA589077
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100 μL
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PIPA589077 100 μL
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Catalog No. PIPA589077 Supplier Invitrogen™ Supplier No. PA589077
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: MPSEGRCWET LKALRSSDKG RLCYYRDWLL RREDVLEECM SLPKLSSYSG WVVEHVLPHM QENQPLSETS PSSTSASALD QPSFVPKSPD ASSAFSPASP ATPNGTKGKD ESQHTESMVL QSSRGIKVEG CVRMYELVHR MKGTEGLRLW QEEQERKVQA LSEMASEQLK RFDEWKELKQ HKEFQDLREV MEKSSREALG HQEKLKAEHR HRAKILNLKL REAEQQRVKQ AEQERLRKEE GQIRLRALYA LQEEMLQLSQ QLDASEQHKA LLKVDLAAFQ TRGNQLCSLI SGIIRASSES; Positive Samples: Jurkat; Cellular Location: Cytoplasm, Cytoplasm, Nucleus, nuclear pore complex.

The proper expression of gene products in eukaryotic cells relies on efficient transport of mRNA molecules out of the nucleus. Gle1 is an essential mRNA export factor in both human and yeast cells. It associates with the nuclear pore complex (NPC) through hCG1 and NUP155 in mammalian cells and in conjunction with inositol hexakisphosphate (IP6), stimulates Dbp5, a member of the DEAD-box helicase family, triggering mRNP remodeling and facilitating RNA export from the nucleus. Recent evidence suggests that mutations in Gle1 causing defects in mRNA export can result in human disease. At least three isoforms of Gle1 are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GLE1
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 2.16 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene GLE1
Gene Accession No. Q53GS7
Gene Alias 4933405K21Rik; AA553313; GLE1; GLE1 RNA export mediator; GLE1 RNA export mediator (yeast); GLE1 RNA export mediator homolog; GLE1 RNA export mediator-like (yeast; GLE1, RNA export mediator; GLE1L; GLE1-like protein; GLE1-like, RNA export mediator; hGLE1; LCCS; LCCS1; Nucleoporin GLE1
Gene Symbols GLE1
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human GLE1 (NP_0010037221).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2733
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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