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Invitrogen™ GLRA1 Polyclonal Antibody
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Catalog No. PA14661
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200 μg
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PA14661 200 μg
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Catalog No. PA14661 Supplier Invitrogen™ Supplier No. PA14661
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Description

Rabbit Polyclonal Antibody

This antibody is specific for the ~48 kDa alpha 1 and alpha 2 subunits of the Glycine Receptor in Western blots of rat spinal cord and brain stem and in cell extracts, and does not recognize other Glycine Receptor subunits. Immunolabeling is blocked by preadsorption of antibody with the peptide immunogen. Reconstitute with 100 μL PBS.

GLRA1 is a subunit of a pentameric inhibitory glycine receptor, which mediates postsynaptic inhibition in the central nervous system. Defects in GLRA1 are a cause of startle disease (STHE), also known as hereditary hyperekplexia or congenital stiff-person syndrome. Multiple transcript variants encoding different isoforms have been found for GLRA1. Glycine receptors (GlyR) that include GLRA1 are members of the cys-loop family of ligand-gated ion channels, responsible for mediating the inhibitory effects of glycine. GLRA1 are widely distributed throughout the CNS, particularly within the hippocampus, spinal cord and brain stem. Diseases associated with GLRA1 include Hyperekplexia, Hereditary 1 and Hyperekplexia.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GLRA1
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 4 mg/mL
Conjugate Unconjugated
Formulation 5mM Ammonium bicarbonate with no preservative; pH 7.4
Gene GLRA1
Gene Accession No. P07727, P23415, Q64018
Gene Alias GLRA; Glra1; Glra2; glycine receptor; Glycine receptor 48 kDa subunit; glycine receptor alpha 1; glycine receptor strychnine-binding subunit; Glycine receptor subunit alpha-1; glycine receptor, alpha 1; glycine receptor, alpha 1 subunit; Glyr; GLYRA1; gra1; HKPX1; nmf11; oscillator; ot; spasmodic; spd; STHE
Gene Symbols GLRA1
Host Species Rabbit
Immunogen Synthetic peptide corresponding to the N-terminal region of rat GLRA1 conjugated to KLH.
Purification Method Affinity chromatography
Quantity 200 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 14654, 25674, 2741
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG
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