Invitrogen™ GLRA1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5102668

Catalog No. PIPA5102668

Description

Antibody detects endogenous levels of total GLRA1.

GLRA1 is a subunit of a pentameric inhibitory glycine receptor, which mediates postsynaptic inhibition in the central nervous system. Defects in GLRA1 are a cause of startle disease (STHE), also known as hereditary hyperekplexia or congenital stiff-person syndrome. Multiple transcript variants encoding different isoforms have been found for GLRA1. Glycine receptors (GlyR) that include GLRA1 are members of the cys-loop family of ligand-gated ion channels, responsible for mediating the inhibitory effects of glycine. GLRA1 are widely distributed throughout the CNS, particularly within the hippocampus, spinal cord and brain stem. Diseases associated with GLRA1 include Hyperekplexia, Hereditary 1 and Hyperekplexia.

Specifications

• Antigen: GLRA1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GLRA1
• Gene Alias: GLRA; Glra1; Glra2; glycine receptor; Glycine receptor 48 kDa subunit; glycine receptor alpha 1; glycine receptor strychnine-binding subunit; Glycine receptor subunit alpha-1; glycine receptor, alpha 1; glycine receptor, alpha 1 subunit; Glyr; GLYRA1; gra1; HKPX1; nmf11; oscillator; ot; spasmodic; spd; STHE
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 14654, 25674, 2741
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P07727, P23415, Q64018
• Gene Symbols: GLRA1
• Immunogen: A synthesized peptide derived from human GLRA1(Accession P23415), corresponding to amino acid residues S354-A404.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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