Invitrogen™ GLRA1 Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA5142974

Catalog No. PIPA5142974

Description

Additional Information: The immunizing peptide represents part of the cytoplasmic domain. The antibody is not expected to cross-react with other glycine receptor alpha proteins. This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:128,000.

GLRA1 is a subunit of a pentameric inhibitory glycine receptor, which mediates postsynaptic inhibition in the central nervous system. Defects in GLRA1 are a cause of startle disease (STHE), also known as hereditary hyperekplexia or congenital stiff-person syndrome. Multiple transcript variants encoding different isoforms have been found for GLRA1. Glycine receptors (GlyR) that include GLRA1 are members of the cys-loop family of ligand-gated ion channels, responsible for mediating the inhibitory effects of glycine. GLRA1 are widely distributed throughout the CNS, particularly within the hippocampus, spinal cord and brain stem. Diseases associated with GLRA1 include Hyperekplexia, Hereditary 1 and Hyperekplexia.

Specifications

• Antigen: GLRA1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GLRA1
• Gene Alias: GLRA; Glra1; Glra2; glycine receptor; Glycine receptor 48 kDa subunit; glycine receptor alpha 1; glycine receptor strychnine-binding subunit; Glycine receptor subunit alpha-1; glycine receptor, alpha 1; glycine receptor, alpha 1 subunit; Glyr; GLYRA1; gra1; HKPX1; nmf11; oscillator; ot; spasmodic; spd; STHE
• Host Species: Goat
• Purification Method: Ammonium sulfate precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 14654, 25674, 2741
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.5 mg/mL
• Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P07727, P23415, Q64018
• Gene Symbols: GLRA1
• Immunogen: Peptide with sequence CLQAKDGISVKGAN.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG