Invitrogen™ GLRA1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA14661

Catalog No. PA14661

Description

This antibody is specific for the ~48 kDa alpha 1 and alpha 2 subunits of the Glycine Receptor in Western blots of rat spinal cord and brain stem and in cell extracts, and does not recognize other Glycine Receptor subunits. Immunolabeling is blocked by preadsorption of antibody with the peptide immunogen. Reconstitute with 100 μL PBS.

GLRA1 is a subunit of a pentameric inhibitory glycine receptor, which mediates postsynaptic inhibition in the central nervous system. Defects in GLRA1 are a cause of startle disease (STHE), also known as hereditary hyperekplexia or congenital stiff-person syndrome. Multiple transcript variants encoding different isoforms have been found for GLRA1. Glycine receptors (GlyR) that include GLRA1 are members of the cys-loop family of ligand-gated ion channels, responsible for mediating the inhibitory effects of glycine. GLRA1 are widely distributed throughout the CNS, particularly within the hippocampus, spinal cord and brain stem. Diseases associated with GLRA1 include Hyperekplexia, Hereditary 1 and Hyperekplexia.

Specifications

• Antigen: GLRA1
• Classification: Polyclonal
• Formulation: 5mM Ammonium bicarbonate with no preservative; pH 7.4
• Gene Accession No.: P07727, P23415, Q64018
• Gene Symbols: GLRA1
• Immunogen: Synthetic peptide corresponding to the N-terminal region of rat GLRA1 conjugated to KLH.
• Quantity: 200 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunohistochemistry, Western Blot
• Conjugate: Unconjugated
• Gene: GLRA1
• Gene Alias: GLRA; Glra1; Glra2; glycine receptor; Glycine receptor 48 kDa subunit; glycine receptor alpha 1; glycine receptor strychnine-binding subunit; Glycine receptor subunit alpha-1; glycine receptor, alpha 1; glycine receptor, alpha 1 subunit; Glyr; GLYRA1; gra1; HKPX1; nmf11; oscillator; ot; spasmodic; spd; STHE
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 14654, 25674, 2741
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized