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Invitrogen™ GLRA4 Polyclonal Antibody
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Catalog No. PIPA560817
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100 μL
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PIPA560817 100 μL
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Catalog No. PIPA560817 Supplier Invitrogen™ Supplier No. PA560817
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: IRLRRRQRRQ RLEEDIIQES RFYFRGYGLG HCLQARDGGP MEGSGIYSPQ PPAPLLREGE TTRKLYVD Highest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 81%.

Glra4 is a member of glycine receptors (GlyR), a cys-loop family of ligand-gated ion channels responsible for mediating the inhibitory effects of glycine. GlyR are widely distributed throughout the CNS, particularly within the hippocampus, spinal cord and brain stem. Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine and channel opening is also triggered by taurine and beta-alanine. Glra4 plays a role in the down-regulation of neuronal excitability, and contributes to the generation of inhibitory postsynaptic currents. The Glra4 gene encodes a protein which has a neurotransmitter-gated ion-channel ligand binding domain. Glra4 protein is very similar to a mouse protein which is a subunit of the retinal glycine receptor. Multiple transcript variants encoding different isoforms have been found for the Glra4 gene. Diseases associated with GLRA4 include Pelizaeus-Merzbacher Disease.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GLRA4
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene GLRA4
Gene Accession No. 0
Gene Alias Glra4; glycine receptor alpha 4; glycine receptor subunit alpha-4; glycine receptor, alpha 4; glycine receptor, alpha 4 subunit; RGD1564103
Gene Symbols GLRA4
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human GLRA4. Recombinant protein control fragment (Product #RP-100486).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 441509
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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