Invitrogen™ GLRB Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA536958

Catalog No. PIPA536958

Description

This antibody detects endogenous protein at a molecular weight of 58 kDa. Purity is >95% by SDS-PAGE.

In the central nervous system (CNS), glycine-mediated inhibitory neurotransmission is essential to voluntary motor control and reflex responses. Glycine binds to glycine receptors (GlyR) in the postsynaptic neuronal membranes. GlyR, gamma-aminobutryic acid, serotonin and acetylcholine comprise an evolutionally conserved superfamily of ligand-gated ion channels. The pentameric subunit structure of GlyR consists of two types of glycosylated membrane proteins, alpha1 through alpha4 and beta, and an associated peripheral membrane protein, which combine to form a chloride-selective ion channel. In humans, the composition of the pentamer changes from alpha2 subunits in the fetal CNS to alpha1 and beta subunits in the adult CNS. Fast potentiation of GlyR by intracellular Ca2+ in the brainstem and midbrain indicate an important role for Ca2+ in modulation of glycinergic synapses.

Specifications

• Antigen: GLRB
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GLRB
• Gene Alias: AI853901; Glrb; glycine receptor; Glycine receptor 58 kDa subunit; glycine receptor beta; glycine receptor subunit beta; glycine receptor, beta; glycine receptor, beta subunit; GlyR beta; Glyrb; HKPX2; inhibitory glycine receptor; spa; spastic
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 14658, 25456, 2743
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide; pH 7.2
• Gene Accession No.: P20781, P48167, P48168
• Gene Symbols: GLRB
• Immunogen: Synthetic peptide corresponding to amino acids 252-297 of human GLRB.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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