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Invitrogen™ GLRB Polyclonal Antibody
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Catalog No. PIPA587954
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100 μL
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PIPA587954 100 μL
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Catalog No. PIPA587954 Supplier Invitrogen™ Supplier No. PA587954
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: KEKSSKKGKG KKKQYLCPSQ QSAEDLARVP ANSTSNILNR LLVSYDPRIR PNFKGIPVDV VVNIFINSFG SIQETTMDYR VNIFLRQKWN DPRLKLPSDF RGSDALTVDP TMYKCLWKPD LFFANEKSAN FHDVTQENIL LFIFRDGDVL VSMRLSITLS CPLDLTLFPM DTQRCKMQLE SFGYTTDDLR FIWQSGDPVQ LEKIALPQFD IKKEDIEYGN CTKYYKGTGY YTCVEVIFTL RRQ; Positive Samples: U-251MG, H460, HT-1080, THP-1, Mouse brain, Mouse liver, Mouse eye, Rat brain, Rat liver; Cellular Location: Cell junction, Cell membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse.

In the central nervous system (CNS), glycine-mediated inhibitory neurotransmission is essential to voluntary motor control and reflex responses. Glycine binds to glycine receptors (GlyR) in the postsynaptic neuronal membranes. GlyR, gamma-aminobutryic acid, serotonin and acetylcholine comprise an evolutionally conserved superfamily of ligand-gated ion channels. The pentameric subunit structure of GlyR consists of two types of glycosylated membrane proteins, alpha1 through alpha4 and beta, and an associated peripheral membrane protein, which combine to form a chloride-selective ion channel. In humans, the composition of the pentamer changes from alpha2 subunits in the fetal CNS to alpha1 and beta subunits in the adult CNS. Fast potentiation of GlyR by intracellular Ca2+ in the brainstem and midbrain indicate an important role for Ca2+ in modulation of glycinergic synapses.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GLRB
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 3 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene GLRB
Gene Accession No. P20781, P48167, P48168
Gene Alias AI853901; Glrb; glycine receptor; Glycine receptor 58 kDa subunit; glycine receptor beta; glycine receptor subunit beta; glycine receptor, beta; glycine receptor, beta subunit; GlyR beta; Glyrb; HKPX2; inhibitory glycine receptor; spa; spastic
Gene Symbols GLRB
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 23-265 of human GLRB (NP_0008151).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 14658, 25456, 2743
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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