GLRB Rabbit anti-Human, Polyclonal, Bioss

Catalog No.	Quantity
50-198-4463	100 μL

Catalog No. 50-198-4463 Supplier Bioss Supplier No. BS20450R

Description

Rabbit Polyclonal Antibody

In the central nervous system (CNS), glycine-mediated inhibitory neurotransmission is essential to voluntary motor control and reflex responses. Glycine binds to glycine receptors (GlyR) in the postsynaptic neuronal membranes. GlyR, gamma-aminobutryic acid, serotonin and acetylcholine comprise an evolutionally conserved superfamily of ligand-gated ion channels. The pentameric subunit structure of GlyR consists of two types of glycosylated membrane proteins, alpha1 through alpha4 and beta, and an associated peripheral membrane protein, which combine to form a chloride-selective ion channel. In humans, the composition of the pentamer changes from alpha2 subunits in the fetal CNS to alpha1 and beta subunits in the adult CNS. Fast potentiation of GlyR by intracellular Ca2+ in the brainstem and midbrain indicate an important role for Ca2+ in modulation of glycinergic synapses.

Specifications

• Antigen: GLRB
• Applications: Western Blot
• Classification: Polyclonal
• Concentration: 1 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene: GLRB
• Gene Accession No.: P48167
• Gene Alias: AI853901; Glrb; Glycine receptor 58 kDa subunit; glycine receptor beta; Glycine receptor subunit beta; glycine receptor, beta; glycine receptor, beta subunit; GlyR beta; Glyrb; HKPX2; inhibitory glycine receptor; spa; spastic
• Gene Symbols: GLRB
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide derived from human GLRB.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 2743
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG