GLRX Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-173-0492	Proteintech Group Inc 158041AP150UL	150 μL

Description

GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide reductase. It contains a redox active CXXC motif in a TRX fold and uses a similar dithiol mechanism employed by TRXs for intramolecular disulfide bond reduction of protein substrates. Unlike TRX, GRX has preference for mixed GSH disulfide substrates, in which it uses a monothiol mechanism where only the N-terminal cysteine is required. By altering the redox state of target proteins, GRX is involved in many cellular functions including DNA synthesis, signal transduction and the defense against oxidative stress. Different classes are known including human GRX1 (GLRX) and GRX2, which are members of this subfamily. Also included in this subfamily are the N-terminal GRX domains of proteins similar to human thioredoxin reductase 1 and 3.

Specifications

• Antigen: GLRX
• Applications: Immunocytochemistry, Immunofluorescence, Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse, Rat
• Gene Accession No.: P35754, Q9ESH6, Q9QUH0
• Gene ID (Entrez): 2745, 64045, 93692
• Immunogen: GLRX Fusion Protein Ag8535
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: GLRX

• Concentration: 0.27 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Alias: GLRX, Glutaredoxin 1, GRX, GRX1, Thioltransferase 1, TTase 1
• Gene Symbols: Glrx
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody