Invitrogen™ GLT-1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA587522

Catalog No. PIPA587522

Description

Positive Samples: MCF7, HepG2, SW480, Mouse liver, Rat liver; Cellular Location: Membrane, Multi-pass membrane protein Immunogen sequence: LDRMRTSVNV VGDSFGAGIV YHLSKSELDT IDSQHRVHED IEMTKTQSIY DDMKNHRESN SNQCVYAAHN SVIVDECKVT LAANGKSADC SVEEEPWKRE K.

Excitatory amino acid transporter 2 (EAAT2) is a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis (ALS.) Alternatively spliced transcript variants of this gene have been identified.

Specifications

• Antigen: GLT-1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SLC1A2
• Gene Alias: 1700091C19Rik; 2900019G14Rik; AI159670; Eaat2; EAAT2 variant mEAAT2/5UT5; excitatory amino acid transporter 2; excitotoxic amino acid transporter 2; glial high affinity glutamate transporter; Glt; GLT1; GLT-1; GLT1a; GLT1b; GLT1c; glutamate transporter 1c; glutamate/aspartate transporter II; GLUT-R; HBGT; high affinity glucose transporter; MGLT1; OTTHUMP00000165209; OTTHUMP00000165210; SLC1A2; Sodium-dependent glutamate/aspartate transporter 2; solute carrier family 1 (glial high affinity glutamate transporter), member 2; solute carrier family 1 member 2; solute carrier family 1, member 2
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 20511, 6506
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot, Immunocytochemistry
• Concentration: 0.18 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P43004, P43006
• Gene Symbols: SLC1A2
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 474-574 of human EAAT2/EAAT2/SLC1A2 (NP_0041622).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG