Invitrogen™ GLTSCR2 Polyclonal Antibody

Catalog No.	Quantity
PIPA570678	100 μL

Catalog No. PIPA570678 Supplier Invitrogen™ Supplier No. PA570678

Description

Rabbit Polyclonal Antibody

This target displays homology in the following species: Human: 100%; Pig: 79%.

Nucleolar protein which is involved in the integration of the 5S RNP into the ribosomal large subunit during ribosome biogenesis. In ribosome biogenesis, may also play a role in rRNA transcription. Also functions as a nucleolar sensor that regulates the activation of p53/TP53 in response to ribosome biogenesis perturbation, DNA damage and other stress conditions. DNA damage or perturbation of ribosome biogenesis disrupt the interaction between NOP53 and RPL11 allowing RPL11 transport to the nucleoplasm where it can inhibit MDM2 and allow p53/TP53 activation. It may also positively regulate the function of p53/TP53 in cell cycle arrest and apoptosis through direct interaction, preventing its MDM2-dependent ubiquitin-mediated proteasomal degradation. Originally identified as a tumor suppressor, it may also play a role in cell proliferation and apoptosis by positively regulating the stability of PTEN, thereby antagonizing the PI3K-AKT/PKB signaling pathway. May also inhibit cell proliferation and increase apoptosis through its interaction with NF2. May negatively regulate NPM1 by regulating its nucleoplasmic localization, oligomerization and ubiquitin-mediated proteasomal degradation. Thereby, may prevent NPM1 interaction with MYC and negatively regulate transcription mediated by the MYC-NPM1 complex. May also regulate cellular aerobic respiration. In the cellular response to viral infection, may play a role in the attenuation of interferon-beta through the inhibition of DDX58/RIG-1.

Specifications

• Antigen: GLTSCR2
• Applications: Western Blot
• Classification: Polyclonal
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene: NOP53
• Gene Accession No.: Q9NZM5
• Gene Alias: 5330430H08Rik; 9430097C02Rik; AU041936; AW536441; glioma tumor suppressor candidate region gene 2; glioma tumor suppressor candidate region gene 2 protein; GLT; GLTSCR2; LOW QUALITY PROTEIN: glioma tumor suppressor candidate region gene 2 protein; NOP53; NOP53 ribosome biogenesis factor; p60; PICT1; PICT-1; preS1 binding protein; PreS1-binding protein; Protein interacting with carboxyl terminus 1; R74911; Ribosome biogenesis protein NOP53
• Gene Symbols: NOP53
• Host Species: Rabbit
• Immunogen: synthetic peptide directed towards the middle region of human GLTSCR2 (aa 380-429).
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 29997
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG