Invitrogen™ Glucagon Monoclonal Antibody (08)

Catalog No.	Quantity
ABS0580802	400 μL

Catalog No. ABS0580802 Supplier Invitrogen™ Supplier No. ABS0580802

Description

Mouse Monoclonal Antibody

Reactivity: ABS 058-08-02 binds free glucagon in solution. ABS 058-08-02 can be used as a detection antibody in a sandwich ELISA with capture antibody ABS 061-09-02. NOTE: Concentration is lot-dependent and can vary from 0.85-1.15 mg/mL.

Glucagon is a 29-residue polypeptide hormone (MW 3482), produced in the pancreas. A related hormone, enteroglucagon (or oxyntomodulin), which is produced in the mucosa of the small and large intestine, consists of the 29 amino acid sequence of pancreatic glucagon extended by 8 additional residues at the C-terminus. The biological activities of pancreatic glucagon include glycogenolysis, lipolysis, gluconeogenesis, and ketogensis, which are antagonistic effects to those of insulin action, thus leading to increased blood glucose levels. Immunocytochemical studies have revealed the presence of pancreatic glucagon inside the A or alpha cells, which constitute 15-20% of the islet cell population. These cells are located preferentially at the periphery of the human pancreatic islets. Pathological manifestations of the glucagon-type peptide residue almost exclusively with the exsistence of tumors or glucagonomas, as no states of glucagon-cell deficiency or hyperplasia have been identified. Glucagon-specific antibodies would prove useful as a cell and tumor markers applying immunohistochemical techniques, and as an analytical tool in qualification of the hormone.

Specifications

• Antigen: Glucagon
• Applications: ELISA
• Classification: Monoclonal
• Clone: 08
• Concentration: 0.93 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 15mM sodium azide; pH 7.4
• Gene: Gcg
• Gene Accession No.: P01274, P01275, P06883
• Gene Alias: GCG; Glicentin; Glicentin-related polypeptide; GLP1; GLP-1; GLP-1(7-36); GLP-1(7-37); GLP1/2; GLP2; GLP-2; Glu; glucagon; Glucagon-like peptide 1; Glucagon-like peptide 1(7-36); Glucagon-like peptide 1(7-37); Glucagon-like peptide 2; glucagon-like peptide-1; GRPP; IL12p35; IL12P40; Incretin hormone; OXM; OXY; Oxyntomodulin; porcine proglucagon; PPG; preproglucagon; proglucagon
• Gene Symbols: Gcg
• Host Species: Mouse
• Immunogen: Synthetic N-terminal fragment of glucagon coupled to carrier.
• Purification Method: Protein A
• Quantity: 400 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 24952, 2641, 397595
• Target Species: Human, Rat, Pig
• Content And Storage: 4°C, store in dark
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1 κ

Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov