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Invitrogen™ Glucagon Polyclonal Antibody
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Catalog No. PIPA583353
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100 μL
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PIPA583353 100 μL
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Catalog No. PIPA583353 Supplier Invitrogen™ Supplier No. PA583353
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: ERHAEGTFTS DVSSYLEGQA AKEFIAWLVK GRGRRDFPEE VAIVEELGRR HADGSFSDEM NTILDNLAAR DFINWLIQ Highest antigen sequence indentity to the following orthologs: Mouse - 96%, Rat - 97%.

Glucagon is a 29-residue polypeptide hormone (MW 3482), produced in the pancreas. A related hormone, enteroglucagon (or oxyntomodulin), which is produced in the mucosa of the small and large intestine, consists of the 29 amino acid sequence of pancreatic glucagon extended by 8 additional residues at the C-terminus. The biological activities of pancreatic glucagon include glycogenolysis, lipolysis, gluconeogenesis, and ketogensis, which are antagonistic effects to those of insulin action, thus leading to increased blood glucose levels. Immunocytochemical studies have revealed the presence of pancreatic glucagon inside the A or alpha cells, which constitute 15-20% of the islet cell population. These cells are located preferentially at the periphery of the human pancreatic islets. Pathological manifestations of the glucagon-type peptide residue almost exclusively with the exsistence of tumors or glucagonomas, as no states of glucagon-cell deficiency or hyperplasia have been identified. Glucagon-specific antibodies would prove useful as a cell and tumor markers applying immunohistochemical techniques, and as an analytical tool in qualification of the hormone.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Glucagon
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.4 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Gcg
Gene Accession No. P01275
Gene Alias GCG; Glicentin; Glicentin-related polypeptide; GLP1; GLP-1; GLP-1(7-36); GLP-1(7-37); GLP1/2; GLP2; GLP-2; Glu; glucagon; Glucagon-like peptide 1; Glucagon-like peptide 1(7-36); Glucagon-like peptide 1(7-37); Glucagon-like peptide 2; glucagon-like peptide-1; GRPP; IL12p35; IL12P40; Incretin hormone; OXM; OXY; Oxyntomodulin; porcine proglucagon; PPG; preproglucagon; proglucagon
Gene Symbols Gcg
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human GCG. Recombinant protein control fragment (Product #RP-102746).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2641
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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