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Glucagon Polyclonal Antibody, Invitrogen™

Catalog No. PIPA588091
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PIPA588091 100 μL
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Catalog No. PIPA588091 Supplier Thermo Scientific Supplier No. PA588091

Item Discontinued This item has been discontinued by the supplier. Please to view product availability in your area.

Description

Rabbit Polyclonal Antibody

Immunogen sequence: RSLQDTEEKS RSFSASQADP LSDPDQMNED KRHSQGTFTS DYSKYLDSRR AQDFVQWLMN TKRNRNNIAK RHDEFERHAE GTFTSDVSSY LEGQAAKEFI AWLVKGRGRR DFPEEVAIVE ELGRRHADGS FSDEMNTILD NLAARDFINW LIQTKITDRK

Glucagon is a 29-residue polypeptide hormone (MW 3482), produced in the pancreas. A related hormone, enteroglucagon (or oxyntomodulin), which is produced in the mucosa of the small and large intestine, consists of the 29 amino acid sequence of pancreatic glucagon extended by 8 additional residues at the C-terminus. The biological activities of pancreatic glucagon include glycogenolysis, lipolysis, gluconeogenesis, and ketogensis, which are antagonistic effects to those of insulin action, thus leading to increased blood glucose levels. Immunocytochemical studies have revealed the presence of pancreatic glucagon inside the A or alpha cells, which constitute 15-20% of the islet cell population. These cells are located preferentially at the periphery of the human pancreatic islets. Pathological manifestations of the glucagon-type peptide residue almost exclusively with the exsistence of tumors or glucagonomas, as no states of glucagon-cell deficiency or hyperplasia have been identified. Glucagon-specific antibodies would prove useful as a cell and tumor markers applying immunohistochemical techniques, and as an analytical tool in qualification of the hormone.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Glucagon
Applications Immunocytochemistry, Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.58 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Gcg
Gene Accession No. P01275, P06883, P55095
Gene Alias GCG, Glicentin, Glicentin-related polypeptide, GLP1, GLP-1, GLP-1(7-36), GLP-1(7-37), GLP1/2, GLP2, GLP-2, Glu, glucagon, Glucagon-like peptide 1, Glucagon-like peptide 1(7-36), Glucagon-like peptide 1(7-37), Glucagon-like peptide 2, glucagon-like peptide-1, GRPP, IL12p35, IL12P40, Incretin hormone, OXM, OXY, Oxyntomodulin, porcine proglucagon, PPG, preproglucagon, proglucagon
Gene Symbols Gcg
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 21-180 of human Pro-glucagon (NP_0020451)
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 14526, 24952, 2641
Target Species Human, Mouse, Rat
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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