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Invitrogen™ GluD1 Recombinant Rabbit Monoclonal Antibody (7L7N2)
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Catalog No. PIMA535668
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PIMA535668 100 μL
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Catalog No. PIMA535668 Supplier Invitrogen™ Supplier No. MA535668
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Description

Rabbit Recombinant Monoclonal Antibody

Immunogen sequence: ERDSNYHLLM SVQESLERKF GKHGGTIPIV PTAEFQDRIS GASEKDIVHS GLAYTMERSA RQIMRTAMKY NLGLDLRTAA YVNAIEKVFK VYNEAGVTFT.

Glutamate dehydrogenase, GluD1, is a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid-induced insulin secretion. It is allosterically activated by ADP and inhibited by GTP and ATP. Activating mutations in this gene are a common cause of congenital hyperinsulinism. Alternative splicing of this gene results in multiple transcript variants. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Related pseudogenes have been identified on chromosomes 10, 18 and X.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GluD1
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Recombinant Monoclonal
Clone 7L7N2
Concentration 0.51 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene GLUD1
Gene Accession No. P00367, P10860, P26443
Gene Alias Ac2-281; AI118167; brain glutamate dehydrogenase; epididymis tissue sperm binding protein Li 18mP; GDH; GDH 1; GDH 2; Gdh1; GDH2; Gdh-X; Glud; GLUD1; GLUD1 protein; GLUD2; Gludeha; Gludl; GLUDP1; gluR delta-1 subunit; GluRdelta1; glutamate dehydrogenase; glutamate dehydrogenase (NAD(P)+); glutamate dehydrogenase 1; glutamate dehydrogenase 1, mitochondrial; glutamate dehydrogenase 2; glutamate dehydrogenase 2, mitochondrial; glutamate dehydrogenase pseudogene 1; glutamate ionotropic receptor delta type subunit 1; glutamate receptor delta-1 subunit; glutamate receptor ionotropic, delta-1; glutamate receptor, ionotropic, delta 1; Grid1; KIAA1220; Membrane protein 50; memory-related gene 2 protein; MP50; MRG-2; testicular secretory protein Li 14
Gene Symbols GLUD1
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence within amino acids 459-558 of human GLUD1 (P00367).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 14661, 24399, 2746
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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