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Invitrogen™ GluD1 Polyclonal Antibody
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Catalog No. PIPA560844
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100 μL
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PIPA560844 100 μL
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Catalog No. PIPA560844 Supplier Invitrogen™ Supplier No. PA560844
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: TFVVQGFGNV GLHSMRYLHR FGAKCIAVGE SDGSIWNPDG IDPKELEDFK LQHGSILGFP KAKPYEGSIL Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 96%.

Glutamate dehydrogenase, GluD1, is a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid-induced insulin secretion. It is allosterically activated by ADP and inhibited by GTP and ATP. Activating mutations in this gene are a common cause of congenital hyperinsulinism. Alternative splicing of this gene results in multiple transcript variants. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Related pseudogenes have been identified on chromosomes 10, 18 and X.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GluD1
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene GLUD1
Gene Accession No. P00367
Gene Alias Ac2-281; AI118167; brain glutamate dehydrogenase; epididymis tissue sperm binding protein Li 18mP; GDH; GDH 1; GDH 2; Gdh1; GDH2; Gdh-X; Glud; GLUD1; GLUD1 protein; GLUD2; Gludeha; Gludl; GLUDP1; gluR delta-1 subunit; GluRdelta1; glutamate dehydrogenase; glutamate dehydrogenase (NAD(P)+); glutamate dehydrogenase 1; glutamate dehydrogenase 1, mitochondrial; glutamate dehydrogenase 2; glutamate dehydrogenase 2, mitochondrial; glutamate dehydrogenase pseudogene 1; glutamate ionotropic receptor delta type subunit 1; glutamate receptor delta-1 subunit; glutamate receptor ionotropic, delta-1; glutamate receptor, ionotropic, delta 1; Grid1; KIAA1220; Membrane protein 50; memory-related gene 2 protein; MP50; MRG-2; testicular secretory protein Li 14
Gene Symbols GLUD1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human Glutamate Dehydrogenase. Recombinant protein control fragment (Product #RP-104374).
Purification Method Antigen Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2746
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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