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Invitrogen™ GRID2 Polyclonal Antibody
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Catalog No. PIPA563583
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100 μL
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PIPA563583 100 μL
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Catalog No. PIPA563583 Supplier Invitrogen™ Supplier No. PA563583
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: AVYEHVRMKG LNPFERDSMY SQMWRMINRS NGSENNVLES QAGIQKVKYG NYAFVWDAAV LEYVAINDPD CSFYTIGNTV ADR Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 98%.

GRID2 is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause cerebellar ataxia in humans.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GRID2
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene GRID2
Gene Accession No. O43424
Gene Alias B230104L07Rik; cpr; creeper; GluD2; gluR delta-2 subunit; GLURD2; GluRdelta2; glutamate ionotropic receptor delta type subunit 2; glutamate receptor; glutamate receptor delta-2 subunit; glutamate receptor ionotropic, delta-2; glutamate receptor, ionotropic, delta 2; Grid2; ho; hotfoot; Lc; Lc>J>; lurcher; minisatellite 10ac detected by probe MMS10; MMS10-AC; Ms10ac; nmf408; SCAR18; tpr
Gene Symbols GRID2
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human GRID2. Recombinant protein control fragment (Product #RP-101821).
Purification Method Antigen Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2895
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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