Invitrogen™ GluR2/GluR3/GluR4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA517314

Catalog No. PIPA517314

Description

It is not recommended to aliquot this antibody.

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, Gria1-4. The subunit encoded by this gene (Gria2) is subject to RNA editing (Q/R and R/G), which is thought to render the channels impermeable to Ca(2+), and to affect the kinetic aspects of these channels in rat brain. Alternative splicing, resulting in transcript variants encoding different isoforms (flip and flop), has been noted for this gene.

Specifications

• Antigen: GluR2/GluR3/GluR4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GRIA2
• Gene Alias: 2900064I19Rik; AMPA selective glutamate receptor; AMPA-selective glutamate receptor 2; AMPA-selective glutamate receptor 3; AMPA-selective glutamate receptor 4; dJ1171F9.1; GluA2; GluA3; GluA4; Glur2; Glur-2; GLUR3; gluR-3; GLUR4; Glur-4; GLUR4C; Gluralpha3; Gluralpha4; GLURB; gluR-B; GLURC; GluR-C; GLURD; gluR-D; GluR-K2; GluR-K3; glutamate ionotropic receptor AMPA type subunit 2; glutamate ionotropic receptor AMPA type subunit 3; glutamate ionotropic receptor AMPA type subunit 4; glutamate receptor; glutamate receptor 2; Glutamate receptor 3; glutamate receptor 4; glutamate receptor B; glutamate receptor B flip isoform; glutamate receptor C; glutamate receptor channel alpha 4; glutamate receptor channel alpha3 subunit; glutamate receptor ionotropic, AMPA 2; Glutamate receptor ionotropic, AMPA 3; Glutamate receptor ionotropic, AMPA 4; glutamate receptor subunit 3; glutamate receptor, ionotrophic, AMPA 3; glutamate receptor, ionotrophic, AMPA 4; glutamate receptor, ionotropic, AMPA 2; glutamate receptor, ionotropic, AMPA 3; glutamate receptor, ionotropic, AMPA 4; glutamate receptor, ionotropic, AMPA2 (alpha 2); glutamate receptor, ionotropic, AMPA3 (alpha 3); glutamate receptor, ionotropic, AMPA4 (alpha 4); Gria2; Gria3; Gria4; HBGR2; Kiaa4184; MRX94; spike wave 1; spkw1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 14800, 14802, 2891, 2892, 2893, 29627, 29628, 29629, 53623
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 270 μg/mL
• Formulation: 0.01M HEPES with 100μg/mL BSA, 50% glycerol, 0.15M NaCl and no preservative; pH 7.5
• Gene Accession No.: P19491, P19492, P19493, P23819, P42262, P42263, P48058, Q9Z2W8, Q9Z2W9
• Gene Symbols: GRIA2, GRIA3, GRIA4
• Immunogen: Synthetic peptide corresponding to residues surrounding Ser720 of human GluR2.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG