Invitrogen™ GluR2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA587355

Catalog No. PIPA587355

Description

Immunogen sequence: NSIQIGGLFP RGADQEYSAF RVGMVQFSTS EFRLTPHIDN LEVANSFAVT NAFCSQFSRG VYAIFGFYDK KSVNTITSFC GTLHVSFITP SFPTDGTHPF VIQMRPDLKG ALLSLIEYYQ WDKFAYLYDS DRGLSTLQAV LDSAAEKKWQ VTAINVGNIN NDKKDEMYRS LFQDLELKKE RRVILDCERD KVNDIVDQVI TIGKHV; Positive Samples: SH-SY5Y, HL-60, Mouse liver, Mouse brain, Mouse pancreas, Rat brain; Cellular Location: Cell junction, Cell membrane, Endoplasmic reticulum membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse.

The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by alpha-amino-3-hydroxy-5 -methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR). The AMPAR are comprised of four distinct Glutamate Receptor Subunits designated (GluR1-4) and they play key roles in virtually all excitatory neurotransmission in the brain. The GluR2 subunit is thought to play a key role in forms of synaptic plasticity such as LTD.

Specifications

• Antigen: GluR2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Gria2
• Gene Alias: AMPA selective glutamate receptor; AMPA-selective glutamate receptor 2; GluA2; Glur2; GluR-2; GLURB; GluR-B; GluR-K2; glutamate ionotropic receptor AMPA type subunit 2; glutamate receptor; glutamate receptor 2; glutamate receptor B; glutamate receptor B flip isoform; glutamate receptor ionotropic, AMPA 2; glutamate receptor, ionotropic, AMPA 2; glutamate receptor, ionotropic, AMPA2 (alpha 2); GRIA2; HBGR2; OTTHUMP00000165324; OTTHUMP00000220942; OTTHUMP00000220943
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 14800
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.52 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P23819
• Gene Symbols: Gria2
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 25-230 of human GluR2/GluR2/GRIA2 (NP_0010770881).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Mouse, Rat
• Product Type: Antibody
• Isotype: IgG