Invitrogen™ GluR6 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA596001

Catalog No. PIPA596001

Description

Immunogen sequence: QGTTHVLRFG GIFEYVESGP MGAEELAFRF AVNTINRNRT LLPNTTLTYD TQKINLYDSF EASKKACDQL SLGVAAIFGP SHSSSANAVQ SICNALGVPH IQTRWKHQVS DNKDSFYVSL YPDFSSLSRA ILDLVQFFKW KTVTVVYDDS TGLIRLQELI KAPSRYNLRL KIRQLPADTK DAKPLLKEMK RGKEFHVIFD CSHEMAAGIL KQALAMGMMT EYYHYIFTTL DLFALDVEPY RYSGVNMTGF RILNTENTQV SSIIEKWSME R; Positive Samples: SW620, U-251MG; Cellular Location: Cell junction, Cell membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse.

Glutamate receptors are the primary excitatory neurotransmitter receptors in the mammalian brain and are activated during various normal neurophysiological processes. The kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels, includes this gene product. The subunit encoded by this gene is edited at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Furthermore, different isoforms of this gene have been described due to alternatively spliced transcript variants. Mutations in this gene have been linked to autosomal recessive cognitive disability. GRIK2-associated diseases include Neurodevelopmental Disorder with Impaired Language and Ataxia and with or without Seizures and Intellectual Developmental Disorder, Autosomal Recessive 6.

Specifications

• Antigen: GluR6
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GRIK2
• Gene Alias: AW124492; bA487F5.1; EAA4; Excitatory amino acid receptor 4; GLR 6; GLR6; GluK2; GLUK6; GLUR 6; gluR beta-2; Glur6; Glur-6; Glurbeta2; glutamate ionotropic receptor kainate type subunit 2; glutamate receptor; glutamate receptor 6; Glutamate receptor beta-2; glutamate receptor form A; glutamate receptor form B; glutamate receptor form C; glutamate receptor form D; glutamate receptor form E; glutamate receptor ionotropic, kainate 2; glutamate receptor, ionotropic kainate 2; glutamate receptor, ionotropic, kainate 2; glutamate receptor, ionotropic, kainate 2 (beta 2); glutamate receptor, ionotropic, kainate 5; GRIK 2; Grik2; GRIK2 protein; grik2alpha; grik2l; MRT6
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 14806, 2898
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.54 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P39087, Q13002
• Gene Symbols: GRIK2
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 30-300 of human GRIK2 (NP_0687751).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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