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Invitrogen™ GluR6 Polyclonal Antibody
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Catalog No. PIPA5102526
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100 μL
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PIPA5102526 100 μL
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Catalog No. PIPA5102526 Supplier Invitrogen™ Supplier No. PA5102526
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total GRIK2.

Glutamate receptors are the primary excitatory neurotransmitter receptors in the mammalian brain and are activated during various normal neurophysiological processes. The kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels, includes this gene product. The subunit encoded by this gene is edited at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Furthermore, different isoforms of this gene have been described due to alternatively spliced transcript variants. Mutations in this gene have been linked to autosomal recessive cognitive disability. GRIK2-associated diseases include Neurodevelopmental Disorder with Impaired Language and Ataxia and with or without Seizures and Intellectual Developmental Disorder, Autosomal Recessive 6.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GluR6
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene GRIK2
Gene Accession No. P39087, P42260, Q13002
Gene Alias AW124492; bA487F5.1; EAA4; Excitatory amino acid receptor 4; GLR 6; GLR6; GluK2; GLUK6; GLUR 6; gluR beta-2; Glur6; Glur-6; Glurbeta2; glutamate ionotropic receptor kainate type subunit 2; glutamate receptor; glutamate receptor 6; Glutamate receptor beta-2; glutamate receptor form A; glutamate receptor form B; glutamate receptor form C; glutamate receptor form D; glutamate receptor form E; glutamate receptor ionotropic, kainate 2; glutamate receptor, ionotropic kainate 2; glutamate receptor, ionotropic, kainate 2; glutamate receptor, ionotropic, kainate 2 (beta 2); glutamate receptor, ionotropic, kainate 5; GRIK 2; Grik2; GRIK2 protein; grik2alpha; grik2l; MRT6
Gene Symbols GRIK2
Host Species Rabbit
Immunogen A synthesized peptide derived from human GRIK2(Accession Q13002), corresponding to amino acid residues T385-V435.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 14806, 2898, 54257
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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